Endocrine Abstracts

Background and aims: Long-acting somatostatin analogues (SAs) are an established treatment for functional symptoms of neuroendocrine tumours (NETs) and also for their known anti-tumour effect. Discussion with colleagues highlighted variations in their use in practice, surrounding test-dosing and treatment doses of SAs.Methods: In 2016 an electronic survey of SA use was undertaken to illuminate actual practice in the UK. Questions focused on test-dosing, ...

Case: A 36-year-old gentleman presented with two month history of severe headaches, vomiting, polyuria and polydipsia. He reported profound episodic sweating especially on exertion and gradual weight loss. He was hypertensive (220/110 mmHg) at presentation. He had no palpitations, anxiety, dizziness, flushing or pallor. He had no diarrhoea or abdominal pain. His only family history was of Type 2 diabetes mellitus.Investigation: Biochemical investigations...

Introduction: Herein we provide clinical, biochemical, histological and radiological evidence of a rare case of a male patient who was diagnosed with pituitary macroadenoma (prolactinoma), phaeochromocytoma and a lung typical-carcinoid tumour on a background of SDH gene mutation encoding the succinate dehydrogenase enzyme.Presentation of case: A 42 year old male individual, was initially diagnosed with a pi...

Introduction: Herein we provide clinical, biochemical, histological and radiological evidence of a rare case of a male patient who was diagnosed with pituitary macroadenoma (prolactinoma), phaeochromocytoma and a lung typical-carcinoid tumour on a background of SDH gene mutation encoding the succinate dehydrogenase enzyme.Presentation of case: A 42 year old male individual, was initially diagnosed with a pi...

We present the case of a 64 year old woman who presented with one month history of tiredness and 8 kg weight loss. Severe hypokalemia (2.2 mmol/l) was identified by the GP. Clinically she appeared mildly Cushingoid. Biochemical investigations showed a random cortisol significantly elevated at 2170 nmol/l, 24-hour urinary cortisol was 15 700 nmol/l(0−135). ACTH level was elevated at 7400 ng/l(0−40). The low dose dexamethasone suppression test demonstrated failure to...

We present the case of a 51-year-old woman who attends the NET service at the Oxford University Hospitals Trust with multiple known secretory paragangliomas (predominantly 3-methoxythyramine), including a carotid body tumour and, most recently, an intrapericardial paraganglioma. She is SDHC mutation positive. Multiple surgical resections of paragangliomas, at sites other than the cardiac lesion, had previously been undertaken. Due to disease progression and symptomati...

Gallium68-Dotatate PET-CT is a somatostatin-receptor (SSTR) based imaging modality employed in the diagnosis and follow-up of Neuroendocrine Tumours (NET). We set out to investigate the incidence of incidental findings, some of which are related to SSTR expression, in our NET patient cohort in Oxford University Hospital. Sixty-eight patients underwent Gallium68-Dotatate PET-CT between June 2020 and June 2021. 40 patients (59%) were female, and median age ...